Pathophysiology of Obesity

Part 1: Physiologic Regulation of Body Weight and Body Composition

Presented by Steven Heymsfield, MD

Learning Objectives: 
- Describe the key features and regulatory pathway for dietary supplements for weight loss.
- Identify the ingredients and their effectiveness that comprise dietary supplements.

Part 2: Energy Homeostasis: Role of Energy Expenditure in Weight Regulation

Presented by Eric Ravussin, PhD

Learning Objectives:
- You will learn that energy balance is not simply derived from energy intake and energy expenditure but needs to consider fat, carbohydrate and protein balances as different entities.  
- You will also be presented with data showing that a low energy expenditure, a low fat oxidation and a low sympathetic activity are all risk factors for weight gain.
- Finally, the concept of metabolic adaptation will be discussed.    

Part 3: Obesity and the Brain: Why and How Surgery and Pharmacotherapy work

Presented by Christopher D. Morrison, PhD

Learning Objectives:
- Generally understand how interoceptive mechanisms coordinate food intake in response to changes in nutritional state.
- Understand the mechanisms through which nutritional information is communicated to the brain.
- Understand the role of the brain in the weight loss effects of GLP1-based pharmaceuticals and bariatric surgery